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Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin

2014; Oxford University Press; Volume: 6; Issue: 11 Linguagem: Inglês

10.1039/c4mt00238e

1756-591X

Nasma D. Eljack, M. Ho-Yu, Janine Drucker, Clara Shen, Trevor W. Hambley, Elizabeth J. New, Thomas Friedrich, Ronald J. Clarke,

Drug Transport and Resistance Mechanisms

Cisplatin is capable of passively diffusing across a lipid bilayer and has no absolute requirement for any protein-mediated uptake mechanism.