In vivo Distribution of Integrins in Renal Cell Carcinoma: Integrin-Phenotype Alteration in Different Degrees of Tumor Differentiation and VLA-2 Involvement in Tumor Metastasis
1995; Mary Ann Liebert, Inc.; Volume: 10; Issue: 4 Linguagem: Inglês
10.1089/cbr.1995.10.287
ISSN2332-4953
AutoresGerasimos Anastassiou, Stefan Duensing, Gustav Steinhoff, Hartmut Kirchner, Arnold Ganser, Jens Atzpodien,
Tópico(s)Protease and Inhibitor Mechanisms
ResumoWe studied 23 renal cell carcinomas and two normal kidney tissues by immunohistochemistry using monoclonal antibodies against subunits of the VLA integrins (VLA-1 to VLA-6) and CD51. All integrins investigated in our study, except VLA-4 (ubiquitous negative), were distributed in different patterns in tumors assayed. We found a correlation between VLA-2 expression and site of tissue; primary tumor cells expressed no VLA-2 integrin, whereas tumor cells from metastatic tissues exhibited VLA-2 positivity (P < .009). Additionally, the expression of VLA-3 and VLA-5 correlated with tumor grading; both integrins were undetectable in G1 tumors but widely expressed in G2 and G3 tumors (VLA-3, p < .000; VLA-5, p < .005). Our results suggest that VLA-2 integrin is involved in metastasis of RCC and that poorly differentiated tumor cells have a different integrin phenotype when compared to normal or highly differentiated tumor cells.
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