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Effects of nitroglycerin (trinitrin) on vascular smooth muscle

1970; Elsevier BV; Volume: 12; Issue: 2 Linguagem: Inglês

10.1016/0014-2999(70)90067-1

1879-0712

M. G. Bogaert, A.G. Herman, A.F. De Schaepdryver,

Heart Rate Variability and Autonomic Control

Nitroglycerin (trinitrin) was studied in the intact anesthetised dog, in the perfused femoral artery or lateral saphenous vein of the dog and on isolated vessels (strips) of rabbit and dog. The behaviour of a vascular bed after systematic administration of nitroglycerin was dependent on reflex adjustments of sympathetic tone. The vasodilator effects of nitroglycerin on perfused vessels or vascular strips were dependent on the time of its administration; administration during an existing contraction was much more effective than administration before contraction. That is, a contraction was more easily abolished than prevented. This behaviour of nitroglycerin contrasts with that of acetylcholine or papaverine.