DNA binding studies with cis-Dichlorobis (5(6)-non/chlorosubstituted-2-hydroxymethyl-benzimidazole) platinum(II) complexes
1997; Elsevier BV; Volume: 68; Issue: 1 Linguagem: Inglês
10.1016/s0162-0134(97)00041-x
ISSN1873-3344
Autores Tópico(s)DNA and Nucleic Acid Chemistry
ResumoThe DNA binding properties of two new platinum compounds, cis-[Pt(L)2Cl2]. 2H2O where L is 5(6)-non/chlorosubstituted-2-hhdroxymethylbenzimidazoe, were examined and compared with cisplatin. The platinum compounds (compounds I and II) were used to modify DNA, which was then used in electrophoretic mobility shift assays with the high mobility group (HMG)-domain protein, HMG1. The DNA platinated with these compounds was specifically recognized by HMG1. It was concluded that the adducts formed by compounds I and II distort the DNA in a manner similar to cisplatin diadducts.
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