Once-daily acebutolol and atenolol in essential hypertension: Double-blind crossover comparison
1985; Elsevier BV; Volume: 109; Issue: 5 Linguagem: Inglês
10.1016/0002-8703(85)90705-7
ISSN1097-6744
AutoresA. S. Turner, Joan C. Brocklehurst,
Tópico(s)Analytical Methods in Pharmaceuticals
ResumoAcebutolol was compared to atenolol in 33 patients with mild to moderate essential hypertension (diastolic blood pressure > 95 mm Hg) with the use of a double-blind crossover study design. At 8 weeks of treatment, acebutolol, 400 mg once daily, and atenolol, 100 mg once daily, produced similar significant (p < 0.01) reductions in average mean arterial blood pressure (12% and 11%, respectively) from baseline. Average heart rate at 4 weeks was also significantly reduced (p < 0.01) from baseline (acebutolol, 14.8%; atenolol, 18.3%); the reduction with acebutolol, however, was significantly less (p < 0.05) than that seen with atenolol. Both agents produced similar effects during exercise, and serum drug determinations showed acebutolol to be rapidly metabolized. Acebutolol appeared to be better tolerated: the frequency of side effects with acebutolol (24%) was less than with atenolol (45%). Acebutolol is as effective as atenolol in mild to moderate essential hypertension. Acebutolol appears to be better tolerated and to have a lesser effect on heart rate than atenolol.
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