Mechanism of decarboxylation of 1,3-dimethylorotic acid revisited: Trapping of the reaction intermediate
1998; Elsevier BV; Volume: 39; Issue: 35 Linguagem: Inglês
10.1016/s0040-4039(98)01331-8
ISSN1873-3581
AutoresMichael P. Nakanishi, Weiming Wu,
Tópico(s)Coordination Chemistry and Organometallics
ResumoThe decarboxylation of 1,3-dimethylorotic acid was investigated to study the nature of the reaction intermediate. 6-Benzyl-1,3-dimethyluracil was isolated when the decarboxylation was carried out in benzyl bromide, indicating the involvement of a carbon-6 centered nucleophilic intermediate in the reaction pathway.
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