Activation of platelets in cancer, especially with reference to genesis of disseminated intravascular coagulation
1983; Elsevier BV; Volume: 29; Issue: 1 Linguagem: Inglês
10.1016/0049-3848(83)90122-6
ISSN1879-2472
AutoresYasuhito Yahara, Satoshi Okawa, Y Onozawa, Takeshi Motomiya, Kenjiro Tanoue, Hideya Yamazaki,
Tópico(s)Blood properties and coagulation
ResumoSeventy-five cancer patients were evaluated on a scale of coagulation abnormalities related to DIC, one point given for each of the following criteria fulfilled and the score (0 to 4) being used. 1. Platelet count < 150 × 103/μl. 2. PT prolonged more than 1 sec over control or APTT prolonged more than 10 sec over control. 3. Fibrinogen < 250 mg/dl (mean fibrinogen value of the cancer patients minus 1SD). 4. FDP ≧ 20 μg/ml. The patients were distributed with 27% for score 0, 38% for 1, 20% for 2, 7% for 3 and 8% for 4. Platelet mode volume in score 4 was smaller than that of the other groups. Platelet aggregation by epinephrine was decreased in score 3 and 4 (P < 0.01), while it was increased in score 0 (P < 0.05). ADP-induced aggregation was increased in score 0 and 1 (P < 0.01 – 0.05). The mean value of β-thromboglobulin in cancer patients (44 ± 24 ng/ml) was significantly higher than that of control (22 ± 13 ng/ml) (P < 0.01). These results suggest the existence of hyperfunction of platelets in cancer patients and possibility of a triggering mechanism of such activated platelets in the genesis of DIC in cancer.
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