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Cáncer de mama metastásico: Caracterización de una cohorte según subtipos

2014; Q16635223; Volume: 142; Issue: 4 Linguagem: Inglês

10.4067/s0034-98872014000400003

0717-6163

César Sánchez, Francisco Acevedo, Militza Petric G, Héctor Galindo, Francisco Domínguez C, Augusto León R, Dravna Razmilic, Carolina Wiesner, Fernando Espinoza, M. Elena Navarro O, D Oddó, Mauricio Camus,

Cancer Diagnosis and Treatment

Survival of patients with metastatic breast cancer according to pathological types of tumorsBackground: The prognosis of breast cancer (BC) is in part determined by the stage at diagnosis and its pathological characteristics.Aim: To evaluate the association between survival of women with metastatic breast cancer and pathological features of the tumor.Patients and Methods: We obtained clinical and pathological data from patients diagnosed with a metastatic BC between 1999 and 2013.The expression of estrogen (ER) and progesterone (PR) receptors and human epidermal growth factor receptor 2 (HER2) was determined by immunohistochemistry. Clinicopathological subtypes were defined as: Luminal A: ER or PR positive, HER2 negative, histological grade (HG) 1 or 2; Luminal B: ER or PR positive, HER2 negative or positive or HG 3; triple negative (TN): ER, PR and HER2 negative, independent of the HG, positive HER2: ER, PR negative and HER2 positive, independent of HG.We analyzed survival based on these subtypes.Results: We identified 54 patients aged 24 to 85 years, with metastatic BC at diagnosis.Seventy five percent had luminal tumors; 19.6% HER2 positive and 7.8% were TN.In 61% of evaluable tumors, HG was classified as 3.The frequency of HER2 positive and high HG tumors was greater in these patients with metastatic BC than in a non-metastatic local BC cohort.Survival was higher among patients with Luminal tumors than in women with non-Luminal cancer (56.4 and 11.4 months, respectively, p = 0.04).Conclusions: Patients with metastatic BC at diagnosis often had HER2 positive tumors and high HG.As in other studies, ER positive tumors had a better survival.(