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Matrix Gla protein, a new γ-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone

1983; Elsevier BV; Volume: 117; Issue: 3 Linguagem: Inglês

10.1016/0006-291x(83)91663-7

1090-2104

Paul A. Price, Marshall R. Urist, Yoko Otawara,

Peroxisome Proliferator-Activated Receptors

A new protein has been isolated from CaCl2/urea extracts of demineralized bovine bone matrix. This protein has five to six residues of the vitamin K-dependent amino acid, gamma-carboxyglutamic acid (Gla), and we have accordingly designated it matrix Gla protein. Matrix Gla protein is a 15,000 dalton protein whose amino acid composition includes a single disulfide bond. The absence of 4-hydroxyproline in matrix Gla protein demonstrates that it is not a precursor to bone Gla protein, 5,800 dalton protein which has a residue of 4-hydroxyproline at position 9 in its sequence. Matrix Gla protein also does not cross-react with antibodies raised against bone Gla protein.