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Fuchs Heterochromic Iridocyclitis—Syndrome, Disease, or Both?

2009; Elsevier BV; Volume: 148; Issue: 4 Linguagem: Inglês

10.1016/j.ajo.2009.06.007

1879-1891

Emmett T. Cunningham, Edoardo Baglivo,

Systemic Lupus Erythematosus Research

Ernst Fuchs, perhaps best known for his landmark "Textbook of Ophthalmology" first published in 1889, headed the Second Clinic of Ophthalmology at the University of Vienna from 1885 to 1915. 1 Muller A. McGhee C.N.J. Professor Ernst Fuchs (1851–1930) A defining career in ophthalmology. Arch Ophthalmol. 2003; 121: 888-891 Crossref PubMed Scopus (8) Google Scholar During this period, Fuchs' extensive clinical and histopathologic studies provided the first detailed descriptions of more than a dozen ocular findings and conditions, 1 Muller A. McGhee C.N.J. Professor Ernst Fuchs (1851–1930) A defining career in ophthalmology. Arch Ophthalmol. 2003; 121: 888-891 Crossref PubMed Scopus (8) Google Scholar including a series of 38 patients with complicated heterochromia, whom he characterized as having iris heterochromia, cyclitis, and cataract. 2 Fuchs E. Umber komplikationen der Heterochromie. Z Augenheilkd. 1906; 15: 191-212 Google Scholar Later studies have variously referred to this syndrome as Fuchs Heterochromic Cyclitis, Fuchs Heterochromic Iridocyclitis, Fuchs Heterochromic Uveitis, or, most recently, Fuchs Uveitis Syndrome (FUS). Subsequently described features of FUS have included a mild anterior chamber reaction with little or no ciliary injection or pain, the occurrence of small to medium-sized diffusely distributed stellate keratic precipitates, iris atrophy with or without heterochromia, and late-onset ocular hypertension or glaucoma. Patients may also have small, often subtle iris nodules at or near the papillary margin, abnormal vessels in the iridocorneal angle, vitritis, one or more chorioretinal scars, and mild late leakage from and staining of the disc on fluorescein angiography. Up to 10% of patients have bilateral involvement, which can complicate the detection of characteristic iris changes. Posterior synechiae formation and the development of cystoid macular edema, either prior to or following cataract surgery, are uncommon. Although anti-inflammatory treatments have little effect on the severity or course of intraocular inflammation in patients with FUS, therapeutic interventions may be needed to address ocular hypertension, cataract formation, or visually significant vitritis. 3 Jones N.P. Fuchs heterochromic uveitis: an update. Surv Ophthalmol. 1993; 37: 253-272 Abstract Full Text PDF PubMed Scopus (130) Google Scholar , 4 Mohamed Q. Zamir E. Update on Fuchs' uveitis syndrome. Curr Opin Ophthalmol. 2005; 16: 356-363 Crossref PubMed Scopus (107) Google Scholar A Cross-sectional and Longitudinal Study of Fuchs Uveitis Syndrome in Turkish PatientsAmerican Journal of OphthalmologyVol. 148Issue 4PreviewTo describe Turkish patients with Fuchs uveitis syndrome (FUS). Full-Text PDF