Etonitazene: An opioid selective for the mu receptor types
1993; Elsevier BV; Volume: 52; Issue: 18 Linguagem: Inglês
10.1016/0024-3205(93)90118-m
ISSN1879-0631
AutoresMarjorie S. Moolten, Jordan B. Fishman, Jin‐Chung Chen, Kristin R. Carlson,
Tópico(s)Receptor Mechanisms and Signaling
ResumoSpecific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu1, mu2, delta, kappa1 and sigma receptors. Both etonitazene and morphine displayed a mu1-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type. The latter result is consistent with the relative potencies of morphine and etonitazene in various behavioral tests.
Referência(s)