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Genetic effects of fungicides

1970; Elsevier BV; Volume: 10; Issue: 6 Linguagem: Inglês

10.1016/0027-5107(70)90081-3

1873-135X

D. Siebert, Friedrich K. Zimmermann, E. Lemperle,

Plant tissue culture and regeneration

14 fungicides have been tested for genetic activity on diploid cells of the ascomycete Saccharomyces cerevisiae. The test system used was induction of: (1) mistotic gene conversion at 2 different loci; and (2) cytoplasmic respiratory-deficient mutants. 2 fungicides turned out to be strongly active in inducing mitotic gene conversion when applied as commercial preparations: Ortho-phaltan (N-(trichloromethylthio)phthalimide) and Polyram-combi (ammonia complex of zinc ethylenebis-(dithiocarbamate) and polyethylenebis(thiocarbamoyl)disulfide). Cignolin (1,8-dihydroxyanthranole), used in dermatology, did not induce mitotic gene conversion but induced cytoplasmic respiratory-deficient mutation at frequencies close to 100%. With 4 more fungicides only a week apparent induction of gene conversion could be observed: Antracol (zinc propylenebis(dithiocarbamate)), Basfungin (ammonia complex of zinc propylenebis (dithiocarbamate) and polypropylenebis(thiocarbamoyl)-disulfide), Dithane-Ultra (manganese-zinc ethylenebis(dithiocarbamate) complex) and Captan (N-(trichloromethylthio)-4-cyclohexene-1,2-dicarbaximide).