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HNF-4α: from MODY to late-onset type 2 diabetes

2004; Elsevier BV; Volume: 10; Issue: 11 Linguagem: Inglês

10.1016/j.molmed.2004.09.004

1471-499X

Rana K. Gupta, Klaus H. Kaestner,

Diabetes and associated disorders

Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4alpha (HNF-4alpha). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4alpha in the human liver and islet, suggesting a very broad role for HNF-4alpha in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4alpha to the much more common late-onset type 2 diabetes.