Sequence of the vanY gene required for production of a vancomycin-inducible D,D-carboxypeptidase in Enterococcus faecium BM4147
1992; Elsevier BV; Volume: 120; Issue: 1 Linguagem: Inglês
10.1016/0378-1119(92)90017-j
ISSN1879-0038
AutoresMichel Arthur, Catherine Molinas, Patrice Courvalin,
Tópico(s)Microbial Metabolism and Applications
ResumoCloning and nucleotide sequencing identified the vanY gene as a member of the vancomycin-resistance van gene cluster of enterococcal plasmid, pIP816. The vanY gene was necessary for synthesis of the vancomycin-inducible d,dcarboxypeptidase activity previously proposed to be responsible for glycopeptide resistance. However, this activity was not required for peptidoglycan synthesis in the presence of glycopeptides. The deduced product of vanY did not display significant similarity with other D,D-carboxypeptidases.
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