Metabolism of ethanol and acetaldehyde in perfused human fetal liver
1971; Elsevier BV; Volume: 10; Issue: 23 Linguagem: Inglês
10.1016/0024-3205(71)90187-1
ISSN1879-0631
Autores Tópico(s)Alcohol Consumption and Health Effects
ResumoThe capacity of the human fetal liver to metabolize ethanol and acetaldehyde was studied by perfusion of hemoglobin-free medium through the liver without re-circulation. Ethanol at concentrations of 0.5 mM and 1.0 nM in the influent medium was not metabolized by the livers of 10 to 16 weeks old human fetuses. The acetaldehyde elimination rate was 0.60 ± 0.26 μmoles/g liver wet wt. per min at acetaldehyde concentration of 1 mM. One third of the acetaldehyde metabolized was reduced to ethanol. Ethanol and acetaldehyde have no influence on the lactate/pyruvate ratio or on the rate of oxygen consumption of the liver. The relations of these findings to the metabolism of the human fetal liver are discussed.
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