Artigo Revisado por pares

Fermentation Development of Recombinant Pichia pastoris Expressing the Heterologous Gene: Bovine Lysozyme

1990; Wiley; Volume: 589; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1990.tb24257.x

ISSN

1749-6632

Autores

R. A. Brierley, Christopher M. Bussineau, Ryszard Kosson, Anthony E. Melton, Robert S. Siegel,

Tópico(s)

Polyamine Metabolism and Applications

Resumo

Annals of the New York Academy of SciencesVolume 589, Issue 1 p. 350-362 Fermentation Development of Recombinant Pichia pastoris Expressing the Heterologous Gene: Bovine Lysozyme R. A. BRIERLEY, R. A. BRIERLEY Salk Institute Biotechnology/Industrial Associates SIBIA San Diego, California 92138Search for more papers by this authorC. BUSSINEAU, C. BUSSINEAU Current address: Chiron Incorporated, Fermentation Division, Emeryville, California.Search for more papers by this authorR. KOSSON, R. KOSSON Salk Institute Biotechnology/Industrial Associates SIBIA San Diego, California 92138Search for more papers by this authorA. MELTON, A. MELTON Salk Institute Biotechnology/Industrial Associates SIBIA San Diego, California 92138Search for more papers by this authorR. S. SIEGEL, R. S. SIEGEL Salk Institute Biotechnology/Industrial Associates SIBIA San Diego, California 92138Search for more papers by this author R. A. BRIERLEY, R. A. BRIERLEY Salk Institute Biotechnology/Industrial Associates SIBIA San Diego, California 92138Search for more papers by this authorC. BUSSINEAU, C. BUSSINEAU Current address: Chiron Incorporated, Fermentation Division, Emeryville, California.Search for more papers by this authorR. KOSSON, R. KOSSON Salk Institute Biotechnology/Industrial Associates SIBIA San Diego, California 92138Search for more papers by this authorA. MELTON, A. MELTON Salk Institute Biotechnology/Industrial Associates SIBIA San Diego, California 92138Search for more papers by this authorR. S. SIEGEL, R. S. SIEGEL Salk Institute Biotechnology/Industrial Associates SIBIA San Diego, California 92138Search for more papers by this author First published: May 1990 https://doi.org/10.1111/j.1749-6632.1990.tb24257.xCitations: 114 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Cregg, J. M., J. F. Tschopp, C. Stillman, R. Siegel, M. Akong, W. S. Craig, R. G. Buckholz, K. R. Madden, P. A. Kellaris, G. R. Davis, B. L. Smiley, J. Cruze, R. Torregrossa, G. Velicelebi & G. P. Thill. 1987. High-level expression and efficient assembly of hepatitis B surface antigen in Pichia pastoris. Bio/Technology 5: 479–485. 2 Digan, M. E., J. Tschopp, L. Grinna, S. V. Lair, W. S. Craig, G. Velicelebi, R. S. Siegel, G. R. Davis & G. P. Thill. 1988. Secretion of heterologous proteins from the methylotrophic yeast, Pichia pastoris. Dev. Ind. Microbiol. 29: 59–69. 3 Digan, M. E., S. V. Lair, R. A. Brierley, R. S. Siegel, M. E. Williams, S. B. Ellis, P. A. Kellaris, S. A. Provow, W. S. Craig, G. Velicelebi, M. M. Harpold & G. P. Thill. 1988. Production of bovine lysozyme via secretion from the yeast, Pichia pastoris. In preparation. 4 Tschopp, J. F., G. Sverlow, R. Kosson & L. Grinna. 1987. High-level secretion of glycosylated invertase in the methylotrophic yeast Pichia pastoris. Bio/Technology 5: 1305–1308. 5 Ellis, S. B., P. F. Brust, P. J. Koutz, A. F. Waters, M. Harpold & T. R. Gingeras. 1985. Isolation of alcohol oxidase and two other methanol regulatable genes from the yeast Pichia pastoris. Mol. Cell. Biol. 5: 1111–1121. 6 Cregg, J. M., K. J. Barringer, A. Y. Hessler & K. R. Madden. 1985. Pichia pastoris as a host system for transformants. Mol. Cell. Biol. 15: 3376–3385. 7 Couderc, R. & J. Baratti. 1980. Oxidation of methanol by the yeast, Pichia pastoris. Purification and properties of the alcohol oxidase. Agric. Biol. Chem. 44: 2279–2289. 8 Siegel, R. S. & R. A. Brierley. 1988. The methylotrophic yeast Pichia pastoris can be produced in high cell density fermentations with high cell yields as a vehicle for recombinant protein production. Biotechnol. Bioeng. In press. 9 Cregg, J. M. & K. R. Madden. 1988. Development of the methylotrophic yeast, Pichia pastoris, as a host system for the production of foreign proteins. Dev. Ind. Microbiol. 29: 23–42. 10 Tschopp, J. F., P. F. Brust, J. M. Cregg, C. A. Stillman & T. R. Gingeras. 1987. Expression of the lacZ gene from two methanol regulatable promoters in Pichia pastoris. Nucleic Acids Res. 15: 3859–3876. 11 Gleeson, M. A. & P. E. Sudbery. 1988. The methylotrophic yeasts. Yeast 4: 1–5. 12 Hazeu, W. & R. A. Donker. 1983. A continuous culture study of methanol and formate utilization by the yeast Pichia pastoris. Biotechnol. Lett. 5: 399–404. 13 Swartz, J. R. & C. L. Cooney. 1981. Methanol inhibition in continuous cultures of Hansenula polymorpha. Appl. Environ. Microbiol. 41: 1206–1213. 14 Anthony, C. 1982. The Biochemistry of Methylotrophs. Academic Press. New York . 15 Ogata, K., H. Nishikawa & M. Ohsuji. 1969. A yeast capable of utilizing methanol. Agric. Biol. Chem. 33: 1519–1520. 16 Veenhuis, J., J. P. Van Dijken & W. Harder. 1983. The significance of peroxisomes in the metabolism of one-carbon compounds in yeasts. Advances in Microbial Physiology 24: 1–82. Academic Press. New York / London . 17 Egli, Th., J. P. Van Dijken, M. Veenhuis, W. Harder & A. Fiechter. 1980. Methanol metabolism in yeasts: regulation and synthesis of catabolic enzymes. Arch. Microbiol. 124: 121–124. 18 Eggling, L. & H. Sahm. 1978. Derepression and partial insensitivity to carbon catabolite repression of the methanol dissimilatory enzymes in Hansenula polymorpha. Eur. J. Appl. Microbiol. Biotechnol. 5: 197–202. 19 Roggenkamp, R., Z. Janowicz, B. Stankowski & C. P. Hollenberg. 1984. Biosynthesis and regulation of the peroxisomal methanol oxidase from the methylotrophic yeast Hansenula polymorpha. Mol. Gen. Genet. 194: 489–493. 20 Sibirny, A. A., V. I. Titorenko, B. D. Efremov & I. I. Toistorkov. 1987. Multiplicity of mechanisms of carbon catabolite repression involved in the synthesis of alcohol oxidase in the methylotrophic yeast Pichia pinus. Yeast 13: 233–241. 21 Van dijken, J. P., R. Otto & W. Harder. 1976. Growth of Hansenula polymorpha in a mixed-limited chemostat. Arch. Microbiol. 111: 137–144. 22 Egli, Th. & A. Fiechter. 1981. Theoretical analysis of media used in the growth of yeasts on methanol. J. Gen. Microbiol. 123: 365–369. 23 Egli, Th. & J. R. Quayle. 1986. Influence of the carbon:nitrogen ratio of the growth medium on the cellular composition and the ability of the methylotrophic yeast Hansenula polymorpha to utilize mixed carbon sources. J. Gen. Microbiol. 132: 1779–1788. 24 Egli, Th., O. Kappeli & A. Fiechter. 1982. Regulatory flexibility of methylotrophic yeasts in continuous culture: simultaneous assimilation of glucose and methanol at fixed dilution rates. Arch. Microbiol. 131: 1–7. 25 Egli, Th., C. Bosshard & G. Hamer. 1986. Simultaneous utilization of methanol-glucose mixtures by Hansenula polymorpha in chemostat: influence of dilution rate and mixture composition on utilization pattern. Biotechnol. Bioeng. 28: 1735–1741. 26 Eggling, L. & H. Sahm. 1981. Enhanced utilization-rate of methanol during growth on a mixed substrate. Arch. Microbiol. 130: 362–365. 27 Mueller, R. H., O. V. Sysoev & W. Babel. 1986. Use of formate gradients for improving biomass yield of Pichia pinus growing continually on methanol. Appl. Microbiol. Biotechnol. 25: 238–244. 28 Shay, L. K., H. R. Hunt & G. H. Wegner. 1987. High-productivity fermentation process for utilizing industrial microorganisms. J. Ind. Microbiol. 2: 79–85. 29 Shugar, D. 1952. Measurement of lysozyme activity and the ultraviolet inactivation of lysozyme. Biochim. Biophys. Acta 8: 302–309. Citing Literature Volume589, Issue1Biochemical EngineeringMay 1990Pages 350-362 ReferencesRelatedInformation

Referência(s)