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BIBTEX RIS

Molecular epidemiology and genomics of group A Streptococcus

2014; Elsevier BV; Volume: 33; Linguagem: Inglês

10.1016/j.meegid.2014.10.011

ISSN

1567-7257

Autores

Debra E. Bessen, W. Michael McShan, Scott V. Nguyen, Amol C. Shetty, Sonia Agrawal, Hervé Tettelin,

Tópico(s)

Antimicrobial Resistance in Staphylococcus

Resumo

Streptococcus pyogenes (group A Streptococcus; GAS) is a strict human pathogen with a very high prevalence worldwide. This review highlights the genetic organization of the species and the important ecological considerations that impact its evolution. Recent advances are presented on the topics of molecular epidemiology, population biology, molecular basis for genetic change, genome structure and genetic flux, phylogenomics and closely related streptococcal species, and the long- and short-term evolution of GAS. The application of whole genome sequence data to addressing key biological questions is discussed.

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