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Endodermal sinus tumor of the vagina

2005; Wiley; Volume: 48; Issue: 5 Linguagem: Inglês

10.1002/pbc.20636

1545-5017

Monica Terenziani, Filippo Spreafico, Paola Collini, Cristina Meazza, Maura Massimino, Luigi Piva,

Urologic and reproductive health conditions

Malignant germ cell tumors of the vagina represent a critical site for local treatment. We report on our experience with two vaginal endodermal sinus tumors. Treatment with PEB regimen induced both tumor regression and alpha fetoprotein normalization. One patient had a residual lesion that was biopsied twice and no viable tumor cells were ever found. Both patients remained alive and disease-free, without having had surgical procedures except for biopsies. Platinum-based chemotherapy is able to achieve complete remissions and should be considered for vaginal endodermal sinus tumors.