Produção Nacional
Revisado por pares
Hormonal Contraceptives and the Length of Their Use Are Not Independent Risk Factors for High-Risk HPV Infections or High-Grade CIN
2010; Karger Publishers; Volume: 71; Issue: 2 Linguagem: Inglês
10.1159/000320742
ISSN1423-002X
AutoresAdhemar Longatto‐Filho, Luciano Serpa Hammes, Luı́s Otávio Sarian, Cecília Roteli-Martins, Sophie Derchain, Mojca Eržen, Margherita Branca, Sílvio Tatti, Paulo Naud, Jean Carlos de Matos, Renata Clementino Gontijo, Marina Y. S. Maeda, Temístocles P. Lima, Silvano Costa, Stina Syrjänen, Karí Syrjänen,
Tópico(s)Genital Health and Disease
Resumo<i>Aims:</i> To evaluate the role of hormonal contraceptives as a risk factor of high-risk human papillomavirus (HR-HPV), cervical intraepithelial lesions (CIN) and cervical cancer in our multi-center population-based LAMS (Latin American Screening) study. <i>Methods:</i> A cohort study with >12,000 women from Brazil and Argentina using logistic regression to analyze the covariates of hormonal contraception (HOC – oral, injections, patches, implants, vaginal ring and progesterone intrauterine system) use followed by multivariate modeling for predictors of HR-HPV and CIN2+. <i>Results:</i> HR-HPV infection was a consistent risk factor of high-grade CIN in all three groups of women. The length of HOC use was not significantly related to high-grade squamous intraepithelial lesions (HSIL)+ Pap (p = 0.069), LSIL+ Pap (p = 0.781) or ASCUS+ (p = 0.231). The same was true with the length of HOC use and histology CIN3+ (p = 0.115) and CIN2+ (p = 0.515). Frequently, HOC users have previously shown more HPV-related lesions, as well as lower HPV prevalence if they were current smokers. But HOC use and time of usage were not independent risk factors of either HR-HPV infection or high-grade CIN using multiple logistic regressions. <i>Conclusions:</i> No evidence was found for an association between the use of HOC with an increased risk for HR-HPV infection or high-grade CIN in this cohort.
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