Characterization of a Tumor Necrosis Factor- α Inhibitor Activity in Cancer Patients
1992; American Thoracic Society; Volume: 6; Issue: 5 Linguagem: Inglês
10.1165/ajrcmb/6.5.510
ISSN1535-4989
AutoresNadine Martinet, Thierry Charles, Pierre Vaillant, Jean-Michel Vignaud, Josette Lambert, Yves Martinet,
Tópico(s)Chronic Obstructive Pulmonary Disease (COPD) Research
ResumoTo evaluate the feasibility of tumor necrosis factor-α (TNF-α) treatment of lung cancer patients, we chose the malignant cells contained in their pleural effusions as a first convenient target. We found, however, that a TNF-α inhibitor (TNF-α I) activity was present in both patient sera and pleural fluids. We therefore compared the TNF-α I activity present in patients with benign or malignant pleural effusions using a bioassay of TNF-α inhibition and partially characterized it. A high TNF-α I activity characterizes cancer patients with sera levels twice as high as the control level measured for blood bank donors (2.54 ± 1.28 versus 1.19 ± 0.38) and with even higher levels in pleural fluids (3.75 ± 1.83). In contrast, patients with benign pleural effusions present similar levels of TNF-α I activity, at about the control level, in both their sera and pleural fluids (1.37 ± 0.98 versus 1.16 ± 0.85). A high TNF-α I activity is consistently found in cancer patients but is only released in vitro by leukocytes. It is most likely related to recently purified TNF-α inhibitors that, as soluble shed fragments of TNF receptors, may function as traps for TNF molecules. This study suggests that tumors may evade TNF cytotoxic action by modulating systemic levels of TNF and implies a reassessment of TNF therapy in cancer patients.
Referência(s)