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Artigo Revisado por pares
BIBTEX RIS

N -(3-Phenoxy-4-pyridinio)methanesulfonamidate

2002; Wiley; Volume: 58; Issue: 2 Linguagem: Inglês

10.1107/s0108270101018595

ISSN

1600-5759

Autores

Catherine Michaux, Caroline Charlier, Fabien Julémont, Jean‐Michel Dogné, Xavier de Leval, Bernadette Norberg, Bernard Pirotte, F. Durant,

Tópico(s)

Synthesis and biological activity

Resumo

The title compound, C12H12N2O3S, is a strict pyridine analogue of nimesulide, a selective inhibitor of cyclooxygen­ase-2. The structure is characterized by a pyridinium ring with a deprotonated sulfon­amide group. An intermolecular charge-assisted hydrogen bond between these two groups is observed within the crystal packing, linking the mol­ecules into an infinite chain running along the b-axis direction.

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