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A Galactosidase‐Responsive “Trojan Horse” for the Selective Targeting of Folate Receptor‐Positive Tumor Cells

2011; Wiley; Volume: 6; Issue: 6 Linguagem: Inglês

10.1002/cmdc.201100114

1860-7187

Mickaël Thomas, Jonathan Clarhaut, Pierre‐Olivier Strale, Isabelle Tranoy‐Opalinski, Joëlle Roche, Sébastien Papot,

HIV/AIDS drug development and treatment

ChemMedChemVolume 6, Issue 6 p. 1006-1010 Communication A Galactosidase-Responsive "Trojan Horse" for the Selective Targeting of Folate Receptor-Positive Tumor Cells Dr. Mickaël Thomas, Dr. Mickaël Thomas Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR-CNRS 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France), Fax: (+33) 549453501Search for more papers by this authorDr. Jonathan Clarhaut, Dr. Jonathan Clarhaut Institut de Physiologie et Biologie Cellulaires, UMR-CNRS 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France) INSERM CIC 0802, 2 rue de la Milétrie, CHU de Poitiers, 86021 Poitiers (France)Search for more papers by this authorPierre-Olivier Strale, Pierre-Olivier Strale Institut de Physiologie et Biologie Cellulaires, UMR-CNRS 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France)Search for more papers by this authorDr. Isabelle Tranoy-Opalinski, Dr. Isabelle Tranoy-Opalinski Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR-CNRS 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France), Fax: (+33) 549453501Search for more papers by this authorProf. Joëlle Roche, Prof. Joëlle Roche Institut de Physiologie et Biologie Cellulaires, UMR-CNRS 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France)Search for more papers by this authorDr. Sébastien Papot, Corresponding Author Dr. Sébastien Papot [email protected] Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR-CNRS 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France), Fax: (+33) 549453501Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR-CNRS 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France), Fax: (+33) 549453501Search for more papers by this author Dr. Mickaël Thomas, Dr. Mickaël Thomas Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR-CNRS 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France), Fax: (+33) 549453501Search for more papers by this authorDr. Jonathan Clarhaut, Dr. Jonathan Clarhaut Institut de Physiologie et Biologie Cellulaires, UMR-CNRS 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France) INSERM CIC 0802, 2 rue de la Milétrie, CHU de Poitiers, 86021 Poitiers (France)Search for more papers by this authorPierre-Olivier Strale, Pierre-Olivier Strale Institut de Physiologie et Biologie Cellulaires, UMR-CNRS 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France)Search for more papers by this authorDr. Isabelle Tranoy-Opalinski, Dr. Isabelle Tranoy-Opalinski Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR-CNRS 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France), Fax: (+33) 549453501Search for more papers by this authorProf. Joëlle Roche, Prof. Joëlle Roche Institut de Physiologie et Biologie Cellulaires, UMR-CNRS 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France)Search for more papers by this authorDr. Sébastien Papot, Corresponding Author Dr. Sébastien Papot [email protected] Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR-CNRS 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France), Fax: (+33) 549453501Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR-CNRS 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers (France), Fax: (+33) 549453501Search for more papers by this author First published: 25 March 2011 https://doi.org/10.1002/cmdc.201100114Citations: 23Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Licence to Kill: A β-galactosidase-responsive molecular "Trojan horse" was designed to selectively kill folate receptor-positive tumor cells. The recognition of the folate membrane receptor is followed by the internalization and the subsequent enzymatic activation of the targeting assembly to release the cytotoxic agent in a stringently controlled fashion exclusively inside the targeted cells. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description cmdc_201100114_sm_miscellaneous_information.pdf1.1 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume6, Issue6June 6, 2011Pages 1006-1010 RelatedInformation