Morphine-Induced Delay of Normal Cell Death in the Avian Ciliary Ganglion
1985; American Association for the Advancement of Science; Volume: 228; Issue: 4706 Linguagem: Inglês
10.1126/science.2990029
ISSN1095-9203
AutoresStephen D. Meriney, D. Bruce Gray, Guillermo Pilar,
Tópico(s)Neuropeptides and Animal Physiology
ResumoRepeated administration of morphine in increasing doses delayed normal cell death in the ciliary ganglion of the chick embryo; the effect was completely blocked by naloxone. Survival of spinal motoneurons was not affected. Morphine also inhibited potassium-stimulated synthesis of acetylcholine in ganglion cells cocultured with muscle, suggesting that morphine can influence neurotransmission. Morphine's effect on cell death may be due to an inhibition of transmission at the neuromuscular junction, but opiates may also directly affect cell death. Although it is not known whether the endogenous opiates in the ciliary ganglion influence neuronal survival during embryogenesis, exogenous opiates can affect normal cell death in the autonomic nervous system.
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