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Dauerhafter intravenöser oder intraarterieller Zugang mit einer subkutan liegenden implantierbaren Infusionskammer: Erste klinische Erfahrungen unter besonderer Berücksichtigung der intraarteriellen Chemotherapie

2008; Thieme Medical Publishers (Germany); Volume: 111; Issue: 20 Linguagem: Inglês

10.1055/s-2008-1068530

1439-4413

M. Lorenz, C. Hottenrott, R. M. Seufert, M. Kirkowa-Reimann, A. Encke,

Chemotherapy-induced cardiotoxicity and mitigation

An infusion chamber was implanted subcutaneously in 18 patients for intravenous systemic treatment and in 20 for intra-arterial treatment of the liver. Intravenous catheters were introduced via the cephalic vein, intra-arterial ones via the gastroduodenal artery, after exclusion of extrahepatic metastases. Six manageable complications were observed during a total implantation time of 102 months for i.v. treatment and usage over 500 days: three temporary occlusions; one infection; two extravasations. The intra-arterial chemotherapy, largely for hepatic metastases of breast carcinoma, was undertaken according to a modified FAM schema (fluorouracil, adriamycin, mitomycin C): It achieved a high response rate with two full and eleven partial remissions. Complications were rare, except for 4 temporary occlusions. Systemic side effects were almost completely absent, local toxicity was low. One problem was the fixation of the needle which connects to the infusion chamber. This was true for both intravenous and intra-arterial treatment.