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Connective Tissue Accumulation in the Muscle Layer in Normal and Varicose Saphenous Veins

1995; SAGE Publishing; Volume: 46; Issue: 3 Linguagem: Inglês

10.1177/000331979504600308

1940-1574

Luís Cristóvão Pôrto, Paulo Roberto Mattos da Silveira, Jorge José de Carvalho, Marília Duarte Brandão Panico,

Peripheral Artery Disease Management

Varicose veins alternate areas of phlebosclerosis and hypertrophy of the vein wall. In this study, samples of long saphenous veins obtained from patients submitted for aortocoro nary saphenous vein graft or for surgical resection of varicose saphenous veins were examined. Histologic changes in the intima, muscle, and adventitial layers were quanti fied. Thicknesses of the venous wall layers were obtained by linear measurements, and the volumetric density of the connective tissue in the muscle layer was determined by point counting. The muscle layer thickness was 300 ±13 and 581 ±25 μm in normal and varicose veins, respectively A more severe connective tissue accumulation within the muscle bundles was found in the varicose condition. The volumetric density of the connective tissue in the circular muscle layer (CmC/MmC) showed also a marked differ ence between varicose (0.67 ±0.08) and normal veins (0.43 ±0.02), P < 0.05. The authors suggest that the varicose condition is associated with a connective tissue uniform accumulation among muscle cells in the circular muscle layer.