Revisão Acesso aberto Revisado por pares

EMERGING PARADIGM

2006; Lippincott Williams & Wilkins; Volume: 26; Issue: 5 Linguagem: Inglês

10.1097/01.shk.0000228797.41044.08

ISSN

1540-0514

Autores

Kevin P. Mollen, Rahul Anand, Allan Tsung, José M. Prince, Ryan M. Levy, Timothy R. Billiar,

Tópico(s)

Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Resumo

The systemic inflammatory response syndrome initiated by infection shares many features in common with the trauma-induced systemic response. The toll-like receptors (TLRs) stand at the interface of innate immune activation in the settings of both infection and sterile injury by responding to a variety of microbial and endogenous ligands alike. Recently, a body of literature has evolved describing a key role for TLRs in acute injury using rodent models of hemorrhagic shock, ischemia and reperfusion, tissue trauma and wound repair, and various toxic exposures. This review will detail the observations implicating a TLR family member, TLR4, as a key component of the initial injury response.

Referência(s)
Altmetric
PlumX