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Metabolism of testosterone in human lung in vitro

1976; Elsevier BV; Volume: 7; Issue: 6-7 Linguagem: Inglês

10.1016/0020-711x(76)90093-8

1878-6014

Jaakko Hartiala, Walter Nienstedt,

Pharmacogenetics and Drug Metabolism

Abstract 1. 1. The metabolism of 4-14C-testosterone in human lung in vitro was investigated. 2. 2. The metabolism was most pronounced in incubations of homogenated tissue, whereas it was rather restricted in the mitochondrial, microsomal and soluble fraction incubations. 3. 3. The by far most prominent metabolite in all experiments was androst-4-ene-3,17-dione. 4. 4. No slfate or glucuronide conjugation took place.