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Hematogenous origin of brain macrophages

1986; Lippincott Williams & Wilkins; Volume: 36; Issue: 6 Linguagem: Inglês

10.1212/wnl.36.6.844

1526-632X

Manuel F. Casanova, Juan C. Troncoso, Donald L. Price,

Neuroinflammation and Neurodegeneration Mechanisms

Del Rio-Hortega believed that phagocytic cells in the CNS arise from microglia; however, recent autoradiographic studies have suggested a hematogenous origin for brain macrophages. To clarify this issue, we studied a young man with acute lymphoblastic leukemia and a peripheral white blood cell count of 22/mm 3 who had an embolic brain infarct 2 weeks before he died. Macrophages were scarce within the lesion, suggesting that the principal phagocytic cell is hematogenous.