Synthesis and applications of heterobifunctional poly(ethylene oxide) oligomers
2007; Elsevier BV; Volume: 49; Issue: 2 Linguagem: Inglês
10.1016/j.polymer.2007.10.029
ISSN1873-2291
AutoresMichael S. Thompson, T. P. Vadala, Michael L. Vadala, Yi‐Rung Lin, Judy S. Riffle,
Tópico(s)Microfluidic and Capillary Electrophoresis Applications
ResumoPoly(ethylene oxide) (PEO) oligomers are employed extensively in pharmaceutical and biomedical arenas mainly due to their excellent physical and biological properties, including solubility in water and organic solvents, lack of toxicity, and absence of immunogenicity. PEO can be chemically modified and reacted with, or adsorbed onto, other molecules and surfaces. Sophisticated applications for PEO have increased the demand for PEO oligomers with tailored functionalities, and heterobifunctional PEOs are often needed. This review discusses the synthesis and applications of heterobifunctional PEO oligomers possessing amine, carboxylate, thiol, and maleimide functional groups.
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