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Cigarette Smoking and Cervical Dysplasia among Non-Hispanic Black Women

1998; Elsevier BV; Volume: 22; Issue: 2 Linguagem: Inglês

10.1046/j.1525-1500.1998.cdoa17.x

1873-443X

Peter A. Kanetsky, Marilie D. Gammon, Jeanne S. Mandelblatt, Zuo‐Feng Zhang, Evangelyn Ramsey, Thomas C. Wright, Louys Thomas, Stephen Matseoane, N Alonso Lázaro, H.T. Felton, Ranjit K. Sachdev, Ralph M. Richart, John P. Curtin,

Endometrial and Cervical Cancer Treatments

This is the first case-control study to determine whether smoking is associated with cervical dysplasia, after adjustment for human papillomavirus (HPV) infection, among a group of non-Hispanic black women. Subjects were interviewed and asked questions about smoking and other risk factors for cervical cancer. HPV infection was determined by hybrid capture. Thirty-two women with histologically confirmed incident dysplasia and 113 control women with normal cytologic smears were enrolled; all women were HIV negative. Smoking was more strongly associated with dysplasia among women with high-grade lesions than among all case women combined. After adjustment, women with high-grade lesions were roughly four times more likely to be ever (odds ratio [OR]: 3.8; 95% confidence interval [CI]: 0.76-18.4) or current (OR: 4.3; 95% CI: 0.83-21.9) smokers, compared with control women. Larger studies among black women that control for HPV infection are needed to confirm these findings and to explore associations among black women with low-grade lesions.