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Hypoxia imaging with [18F]HX4 PET in NSCLC patients: Defining optimal imaging parameters

2013; Elsevier BV; Volume: 109; Issue: 1 Linguagem: Inglês

10.1016/j.radonc.2013.08.031

1879-0887

Catharina M.L. Zegers, Wouter van Elmpt, Roel Wierts, Bart Reymen, Hoda Sharifi, Michel Öllers, Frank Hoebers, Esther G.C. Troost, Rinus Wanders, Angela van Baardwijk, Boudewijn Brans, Jonas Eriksson, Albert D. Windhorst, Felix M. Mottaghy, Dirk De Ruysscher, Philippe Lambin,

Medical Imaging and Pathology Studies

Background and purpose[18F]HX4 is a promising hypoxia PET-tracer. Uptake, spatio-temporal stability and optimal acquisition parameters for [18F]HX4 PET imaging were evaluated in non-small cell lung cancer (NSCLC) patients.Materials and methods[18F]HX4 PET/CT images of 15 NSCLC patients were acquired 2 h and 4 h after injection (p.i.). Maximum standardized-uptake-value (SUVmax), tumor-to-blood-ratio (TBRmax), hypoxic fraction (HF) and contrast-to-noise-ratio (CNR) were determined for all lesions. To evaluate spatio-temporal stability, DICE-similarity and Pearson correlation coefficients were calculated. Optimal acquisition-duration was assessed by comparing 30, 20, 10 and 5 min acquisitions.ResultsConsiderable uptake (TBR >1.4) was observed in 18/25 target lesions. TBRmax increased significantly from 2 h (1.6 ± 0.3) to 4 h p.i. (2.0 ± 0.6). Uptake patterns at 2 h and 4 h p.i. showed a strong correlation (R = 0.77 ± 0.10) with a DICE similarity coefficient of 0.69 ± 0.08 for the 30% highest uptake volume. Reducing acquisition-time resulted in significant changes in SUVmax and CNR. TBRmax and HF were only affected for scan-times of 5 min.ConclusionsThe majority of NSCLC lesions showed considerable [18F]HX4 uptake. The heterogeneous uptake pattern was stable between 2 h and 4 h p.i. [18F]HX4 PET imaging at 4 h p.i. is superior to 2 h p.i. to reach highest contrast. Acquisition time may be reduced to 10 min without significant effects on TBRmax and HF.