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The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential

2014; American Association for Cancer Research; Volume: 12; Issue: 6 Linguagem: Inglês

10.1158/1541-7786.mcr-13-0536

1557-3125

Himisha Beltran,

Pancreatic function and diabetes

Abstract N-myc (MYCN), a member of the Myc family of basic-helix–loop–helix–zipper (bHLHZ) transcription factors, is a central regulator of many vital cellular processes. As such, N-myc is well recognized for its classic oncogenic activity and association with human neuroblastoma. Amplification and overexpression of N-myc has been described in other tumor types, particularly those of neural origin and neuroendocrine tumors. This review outlines N-myc's contribution to normal development and oncogenic progression. In addition, it highlights relevant transcriptional targets and mechanisms of regulation. Finally, the clinical implications of N-Myc as a biomarker and potential as a target using novel therapeutic approaches are discussed. Mol Cancer Res; 12(6); 815–22. ©2014 AACR.