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Simultaneous Determination of Caffeine and Acetylsalicylic Acid in Pharmaceutical Formulations Using a Boron‐Doped Diamond Film Electrode by Differential Pulse Voltammetry

2012; Wiley; Volume: 24; Issue: 5 Linguagem: Inglês

10.1002/elan.201200018

1521-4109

Eric Oliveira Faria, Antônio Carlos Viera Lopes, Dênio Emanuel Pires Souto, Fernando Roberto Figueirêdo Leite, Flávio Santos Damos, Rita de Cássia Silva Luz, Alexandre Soares dos Santos, Diego Leoni Franco, Wallans Torres Pio dos Santos,

Electrochemical sensors and biosensors

Abstract This work presents a simple, fast and low‐cost method for simultaneous determination of acetylsalicylic acid (ASA), without alkaline hydrolysis and caffeine (CF) in pharmaceutical formulations using a boron‐doped diamond as the working electrode through differential pulse voltammetry. A good repeatability was reached for 20 measurements, with a low relative standard deviation of less than 1.0 %. The calibration curves presented a great linear correlation coefficient for both drugs ( R =0.999) with a limit of detection of 1.6×10 −7 mol L −1 for CF and 2.3×10 −7 mol L −1 for ASA. The system was validated in comparison with the official method.