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Aspirin dosage for infants and children

1979; Elsevier BV; Volume: 95; Issue: 4 Linguagem: Inglês

10.1016/s0022-3476(79)80783-0

1097-6833

Paul S. Lietman, Alan K. Done, Sumner J. Yaffe, John M. Clayton,

Poisoning and overdose treatments

The labeled dosage schedule that has long been on pediatric aspirin preparations is at variance with the recommendations in authoritative medical references, studies demonstrating antipyretic effectiveness in children, and the prescribing habits of pediatricians as revealed by a poll conducted by the authors. Aspirin pharmacokinetics are influenced by a number of physiologic factors, as well as by dosage, and complicate the problem of assuring safe and effective pediatric use. Basic pharmacokinetic considerations indicate that the increase in size of individual doses needed to assure therapeutic salicylate blood levels, thereby removing the temptation of parents to administer the drug too often, is made permissible (i.e., safe while effective) by expanding the interdose interval to four hours instead of three. A revised pediatric aspirin dosage schedule is presented that better meets the practices of the pediatric community and the needs of consumers. The labeled dosage schedule that has long been on pediatric aspirin preparations is at variance with the recommendations in authoritative medical references, studies demonstrating antipyretic effectiveness in children, and the prescribing habits of pediatricians as revealed by a poll conducted by the authors. Aspirin pharmacokinetics are influenced by a number of physiologic factors, as well as by dosage, and complicate the problem of assuring safe and effective pediatric use. Basic pharmacokinetic considerations indicate that the increase in size of individual doses needed to assure therapeutic salicylate blood levels, thereby removing the temptation of parents to administer the drug too often, is made permissible (i.e., safe while effective) by expanding the interdose interval to four hours instead of three. A revised pediatric aspirin dosage schedule is presented that better meets the practices of the pediatric community and the needs of consumers. ErratumThe Journal of PediatricsVol. 95Issue 6Preview Full-Text PDF