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Heterogeniety of endothelin/sarafotoxin receptors mediating contraction of the human isolated saphenous vein

1993; Elsevier BV; Volume: 239; Issue: 1-3 Linguagem: Inglês

10.1016/0014-2999(93)91010-k

1879-0712

Willem A. Bax, Egbert Bos, Pramod R. Saxena,

Cardiac electrophysiology and arrhythmias

We investigated the effect of the ETA receptor antagonist, BQ-123 (0.1 and 1 μM), on contraction of the human isolated saphenous vein induced by endothelin-1 or sarafotoxin S6b. Contraction in response to endothelin-1 was not affected by BQ-123. In contrast, BQ-123 biphasically attenuated the contractions due to sarafotoxin S6b. These data indicate that (i) endothelin-1 induces contractions of the human saphenous vein via a non-ETA receptor and (ii) contractions in response to sarafotoxin S6b are mediated in part via a receptor different from the receptor mediating contraction due to endothelin-1.