Carcinoma of the thyroid at a young age—a review of 23 patients
1992; Wiley; Volume: 20; Issue: 1 Linguagem: Inglês
10.1111/j.1365-2559.1992.tb00918.x
ISSN1365-2559
AutoresYusuke Mizukami, Takatoshi Michigishi, Akitaka Nonomura, Takuma Hashimoto, Masakuni Noguchi, F Matsubara, K Watanabe,
Tópico(s)BRCA gene mutations in cancer
ResumoTwenty‐three children and adolescents with thyroid carcinoma who were 20 years old or younger at the time of initial treatment were followed for a mean time of 9.5 years. Of the tumours, 21 were papillary and two follicular carcinomas. The majority (91%) of the 23 cases showed extra‐thyroidal extension of the tumour. An association with chronic thyroiditis was observed in 30% of the cases. There was no history of irradiation of the head and neck in any patients. Relapse occurred in eight patients, lung metastases in two and local recurrences in six; one patient died from lung metastases 3 months after initial treatment. Male patients, advanced stage of tumour, less differentiated histological features and DNA aneuploidy were associated with a higher frequency of relapse. The prognosis of thyroid carcinomas in children and adolescents is not so good as is generally believed.
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