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Vaginal absorption of oestradiol and progesterone

1984; Elsevier BV; Volume: 6; Issue: 4 Linguagem: Inglês

10.1016/0378-5122(84)90009-4

1873-4111

H. Kålund-Jensen, C.J. Myrén,

Estrogen and related hormone effects

The vaginal absorption of micronized oestradiol/progesterone from a hydrophilic matrix system was investigated before and after 10 days of treatment in 7 post-menopausal women with an average age of 56.1 yr. Oestradiol and progesterone levels were measured on days 1 and 11 before administration and 0.5, 1, 2, 3, 4, 6, 8, 12, and 24 h afterwards by radioimmunoassay. Peak values were seen 6-12 h after administration. This finding differs from those of other investigations. Sex hormone binding globulin (SHBG) and androgen concentrations were unchanged after 10 days of treatment.