Synthesis of Fused Bicyclic Imidazoles by Sequential Van Leusen/Ring-Closing Metathesis Reactions
2005; American Chemical Society; Volume: 7; Issue: 15 Linguagem: Inglês
10.1021/ol050852+
ISSN1523-7060
AutoresVijaya Gracias, Alan F. Gasiecki, Stevan W. Djurić,
Tópico(s)Click Chemistry and Applications
Resumo[reaction: see text]. A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.
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