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Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

1994; Elsevier BV; Volume: 4; Issue: 2 Linguagem: Inglês

10.1016/s0960-894x(01)80133-5

1464-3405

Johannes Stoelwinder, Marinella Roberti, Alan P. Kozikowski, Kenneth M. Johnson, John S. Bergmann,

Receptor Mechanisms and Signaling

Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.