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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

An innovative quaternary ammonium methacrylate polymer can provide improved antimicrobial properties for a dental adhesive system

2013; Taylor & Francis; Volume: 24; Issue: 12 Linguagem: Inglês

10.1080/09205063.2013.766784

ISSN

1568-5624

Autores

Yasmine Mendes Pupo, Paulo Vítor Farago, Jéssica Mendes Nadal, Luís Antônio Esmerino, Daniela Florêncio Maluf, Sônia Faria Zawadzki, Milton Domingos Michél, Fábio André dos Santos, Osnara María Mongruel Gómes, João Carlos Gomes,

Tópico(s)

Dental Research and COVID-19

Resumo

A quaternary ammonium methacrylate polymer (QAMP) with antimicrobial potential was synthesized. The resulting product (QAMP) was characterized by FTIR spectroscopy, NMR spectroscopy, visible spectrophotometry, XRPD and TGA. The in vitro susceptibility tests against Streptococcus mutans of QAMP were investigated prior and after incorporation into a commercial adhesive system (Clearfil™ SE Bond). The release of quaternary ammonium compounds from the experimental adhesive system (Clearfil™ SE Bond + 5% QAMP) was performed during 1, 7, 14, 21 and 30 days. Spectroscopic data confirmed that QAMP was successfully obtained. Thermogravimetric analysis indicated that QAMP was heat stable. Prior incorporation into the adhesive system, QAMP revealed an inhibition halo of 18.33 ± 0.6 mm. By agar disk diffusion test, Clearfil™ SE Bond containing 5% QAMP presented an inhibition halo (16.67 ± 1.5 mm) similar to Clearfil™ Protect Bond (positive control, 17.00 ± 1.7, p = 0.815) and significantly higher than Clearfil™ SE Bond (negative control, 11.00 ± 1.0, p = 0.006). The minimum inhibitory/bactericidal concentrations for Clearfil™ SE Bond containing 5% QAMP were 20 μL mL−1. The release of quaternary ammonium compounds from the experimental adhesive containing QAMP was very low (5.1%) when compared to Clearfil™ Protect Bond that released 47.2% of its quaternary ammonium monomer (MDPB) after 30 days. The QAMP can offer enhanced antimicrobial properties for self-etching adhesive systems.

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