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Primary cutaneous cryptococcosis due to Cryptococcus neoformans var. gattii serotype B, in an immunocompetent patient

2002; UNIVERSIDADE DE SÃO PAULO; Volume: 44; Issue: 4 Linguagem: Inglês

10.1590/s0036-46652002000400008

1678-9946

Carlos da Silva Lacaz, Elisabeth Maria Heins‐Vaccari, G. L. Hernandez-Arriagada, Eduardo Lacaz Martins, Célia A.L. PREARO, Simone Miwa Corim, Marilena dos Anjos Martins,

Antifungal resistance and susceptibility

The authors report a male patient, a seller with no detected immunosuppression, with an extensive ulcerated skin lesion localized on the left forearm, caused by Cryptococcus neoformans var. gattii serotype B. Oral treatment with fluconazole was successful. A review of the literature showed the rarity of this localization in HIV-negative patients. In contrast, skin lesions frequently occurs in HIV-positive patients, with Cryptococcus neoformans var. neoformans serotype A predominating as the etiological agent. In this paper, the pathogenicity of C. neoformans to skin lesions in patients immunocompromised or not, is discussed, showing the efficacy of fluconazole for the treatment of these processes.