Effects of posttrial electrical stimulation of hippocampus and caudate nucleus on maze learning in the rat
1968; Elsevier BV; Volume: 3; Issue: 5 Linguagem: Inglês
10.1016/0031-9384(68)90152-2
ISSN1873-507X
AutoresDonald G. Stein, Stephen L. Chorover,
Tópico(s)Memory and Neural Mechanisms
ResumoTen rats with bilateral, monopolar electrodes in hippocampus or caudate nucleus received electrical stimulation (ES) following massed or spaced training trials on a number of maze problems. Animals receiving hippocampal ES after spaced trials showed significantly better retention than comparably trained caudate stimulated or normal controls. Under massed trials only the rats receiving hippocampal ES showed significant disruption of learning. Threshold voltage required for response, and sequence of observed behavior were quantitatively and qualitatively different for hippocampus and caudate nucleus. Hypotheses proposing shifts in motivational level or aversiveness of ES could not satisfactorily explain the results. The data suggest that memory trace consolidation can be facilitated or disrupted by postrial ES.
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