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Diagnosis, and prognosis of AIDS-related cholangitis

1995; Lippincott Williams & Wilkins; Volume: 9; Issue: 8 Linguagem: Inglês

10.1097/00002030-199508000-00007

1473-5571

Michel Ducreux, Catherine Buffet, Pierre‐Jean Lamy, Laurent Beaugerie, Jacques Fritsch, André Daniel Choury, C Liguory, Pascale Longuet, Jean–Pierre Gendre, François Vachon, M Gentilini, Willy Rozenbaum, Y Le Quintrec, Jean-Pierre Etienne,

Pediatric Hepatobiliary Diseases and Treatments

Objective To determine more precisely the clinical, and biological characteristics of AIDS-related cholangitis, and to investigate prognostic variables of this disease. Design Retrospective clinical, and prognostic study. Setting Biliary unit, Bicêtre Hospital, France. Patients HIV-positive patients (n = 52) referred to the unit between December 1986, and June 1993 for biliary symptoms leading to the suspicion of AIDS-related cholangitis, (42 men; 10 women; mean age, 37±8 years). Intervention Endoscopic retrograde cholangiopancreatography (ERCP) was performed in order to determine the cause of the biliary symptoms. Main outcome measure Clinical features, and evolution of the cholangitis. Results Among the 52 patients, 45 met the ERCP criteria of AIDS-related cholangitis (36 men; nine women). The diagnosis of cholangitis was strongly suggested by abdominal ultrasonography in 47% of the cases. ERCP showed papillary stenosis, diffuse cholangitis, extrahepatic cholangitis alone, and intrahepatic cholangitis alone in 60, 67, 7, and 27%, respectively. Endoscopic sphincterotomy was performed in 28 patients. Pain was relieved by sphincterotomy in nine patients, but the other clinical or biological features were not influenced. One-year, and 2-year survival rates were 41 ±7%, and 8±4%, respectively. Multidimensional analysis using a Cox model showed that a lymphocyte count >500±106/l was the only independent predictive factor of better survival. Conclusion AIDS-related cholangitis is a disease which leads preferentially to papillary stenosis or diffuse abnormalities of the biliary tract. Prognostic factors depend on the stage of the HIV infection. Another diagnosis of cholestasis was found in approximately 15% of the patients who showed biliary symptoms.