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Effects of Extracellular Egg Factors on Sperm Guanylate Cyclase

1985; American Association for the Advancement of Science; Volume: 227; Issue: 4688 Linguagem: Inglês

10.1126/science.2857502

1095-9203

Gary E. Ward, David L. Garbers, Victor D. Vacquier,

Neurobiology and Insect Physiology Research

Extracellular factors from the sea urchin egg induce a change in the electrophoretic mobility of an abundant sperm membrane phosphoprotein. The modified protein was identified as guanylate cyclase. The mobility shift of the cyclase was shown to be associated with a decrease in its enzymatic activity.