Portal de Periódicos da CAPES

Cytogenetics of Uterine Sarcomas: Presentation of Eight New Cases and Review of the Literature

1998; Elsevier BV; Volume: 71; Issue: 2 Linguagem: Inglês

10.1006/gyno.1998.5165

1095-6859

Mariola Iliszko, Nils Mandahl, Krzysztof Mrózek, Andrzej Denis, Nikos Pandis, Tania Pejovic, Małgorzata Babińska, Bogusław Nedoszytko, Jarosław Dębniak, Janusz Emerich, M Hrabowska, Clara D. Bloomfield, Janusz Limon,

Endometrial and Cervical Cancer Treatments

Tissue from 14 uterine tumor samples from eight patients—four with endometrial stromal sarcoma (ESS), two with leiomyosarcoma (ULMS), and two with malignant mixed mesodermal tumor (MMMT)—were investigated cytogenetically after short-term culturing. Clonal chromosome aberrations were found in 12 tumors. One ESS showed a recombination between 7p14 and 17q12, a rearrangement characterizing a subset of ESSs. In our series, chromosomes 1, 6, 7, and 16 were involved in structural aberrations most frequently (four cases each). Net loss of 6q material was found in four cases and bands 11q13, 16q13, and 22q13 were each rearranged in four cases. Among 43 uterine sarcomas, including 12 MMTs, now available for evaluation, some differences in breakpoint distribution among different tumor types were found. Rearrangements of bands 1p32, 3p24, and 10q22 were found exclusively in ULMS, whereas aberrations of bands 6p21, 7p21, and 17q12 were found predominantly in ESS.