Lipoproteins, neurobiology, and Alzheimer's disease: structure and function of apolipoprotein E
1994; Elsevier BV; Volume: 4; Issue: 4 Linguagem: Inglês
10.1016/s0959-440x(94)90212-7
ISSN1879-033X
AutoresKarl H. Weisgraber, Robert E. Pitas, Robert W. Mahley,
Tópico(s)S100 Proteins and Annexins
ResumoThe structure of apolipoprotein E has provided unique insights into the role of this protein in lipoprotein metabolism and neurobiology. Isoform-specific differences between apolipoprotein E3 and apolipoprotein E4 have been described with respect to neurite extension by cultured neurons, and interactions with proteins characteristic of the lesions of Alzheimer's disease, such as the amyloid β peptide of neuritic plaques and tau, the microtubule-associated protein of neurofibrillary tangles. Apolipoprotein E may play a part in normal neurobiology and in the pathogenesis of Alzheimer's disease.
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