P8 The effect of demographic and clinical factors on the natural history of viral load in HIV infection
2000; Wiley; Volume: 1; Issue: 3 Linguagem: Inglês
10.1046/j.1468-1293.2000.00024-63.x
ISSN1468-1293
AutoresCaroline Sabin, Alessandro Cozzi Lepri, C Lee, Giovanni Rezza, Margaret Johnson, Amanda Mocroft, Clive Loveday, AN Phillips,
Tópico(s)HIV/AIDS Research and Interventions
ResumoObjective: To study the effect of demographic and clinical factors on RNA trajectories in minimally treated patients. Method: Serial HIV RNA levels have been measured in patients from the Royal Free Haemophilia Cohort, the Ian Charleson Day Centre and the Italian Seroconversion study. Rates of RNA change were estimated using random effects models. RNA levels in the first 18 months after seroconversion (sc), and those after starting PI/NNRTI therapy were excluded; those with > 2 measurements (n = 647) were included. Results: The patients were mainly male (71%), with median age of 26 years at sc. Risk factors were homosexual (25%), IVDU (37%), haemophilic (16%), other (1%). A median of 4 (2–30) RNA levels were available per person. Overall, the mean RNA level 18 months after sc was 3.6 log10 copies/mL; this increased significantly by 0.04 log10 per year. In a multivariate analysis, haemophilic men had significantly lower initial RNA levels and faster rates of increase than other groups, which manifested in higher rates of disease progression. Older age was associated with higher RNA levels after sc, as was being in the UK cohorts. Mean RNA levels were significantly higher, but increased less rapidly in those seroconverting in more recent calendar periods. Conclusion: Patterns of HIV RNA change may differ according to demographic factors. These differences must be considered when interpreting RNA levels in HIV-infected patients.
Referência(s)