Cellular reactions to polyester arterial prostheses impregnated with cross-linked albumin: in vivo studies in mice
1989; Elsevier BV; Volume: 10; Issue: 1 Linguagem: Inglês
10.1016/0142-9612(89)90010-0
ISSN1878-5905
AutoresYanhe Merhi, Raynald Roy, Robert Guidoin, Jacques Hébert, Walid Mourad, Saîdi Benslimane,
Tópico(s)Tissue Engineering and Regenerative Medicine
ResumoThis study was designed to assess the possible immunological responses in mice against polyester prostheses coated with albumin and previously stabilized either with cross-linked glutaraldehyde (GA), at different concentrations, or with carbodiimide (CDI). Prosthetic discs were first implanted in the peritoneal cavities of mice, and T cells and T cell subsets (helper, suppressor, la-bearing T lymphocytes) were then quantified before implantation and at 1, 2, 3 and 4 weeks post-implantation. The percentages of T cells, subsets, and the helper/suppressor cell ratio, as well as the percentage of T cells with la receptors, were similar to the control in all experimental groups. No significant difference and no correlation were observed between the groups wherever tested. Virgin and albumin-coated grafts did not induce any quantitative changes in T cell subpopulations in mice.
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