Intermediates of lysine dissimilation in the yeast, Hansenula saturnus
1965; Elsevier BV; Volume: 111; Issue: 2 Linguagem: Inglês
10.1016/0003-9861(65)90210-9
ISSN1096-0384
Autores Tópico(s)Yeasts and Rust Fungi Studies
ResumoThe yeast Hansenula saturnus can utilize the nitrogen, but not the carbon, of lysine for growth. Incubation of the organism with l-lysine-6-C14 thus resulted in the formation of metabolites directly from the lysine carbon chain, uncomplicated by the presence of products arising from small fragments. The main products which accumulated in the medium included ϵ-acetamido-α-hydroxycaproic acid, δ-acetamidovaleric acid, glutaric acid, and several as yet unidentified compounds. Small amounts of the corresponding free amino acids were also found. ϵ-N-Acetyllysine was identified in the ethanolic cell extracts. The above findings, along with other information, strongly support the idea that lysine is metabolized in H. saturnus by way of series of N-acylated intermediates.
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