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Cell Cycle Arrest by Vpr in HIV-1 Virions and Insensitivity to Antiretroviral Agents

1998; American Association for the Advancement of Science; Volume: 281; Issue: 5374 Linguagem: Inglês

10.1126/science.281.5374.266

1095-9203

Betty Poon, Kathie Grovit‐Ferbas, Sheila A. Stewart, Irvin S. Y. Chen,

T-cell and B-cell Immunology

Expression of human immunodeficiency virus-type 1 (HIV-1) Vpr after productive infection of T cells induces cell cycle arrest in the G2 phase of the cell cycle. In the absence of de novo expression, HIV-1 Vpr packaged into virions still induced cell cycle arrest. Naturally noninfectious virus or virus rendered defective for infection by reverse transcriptase or protease inhibitors were capable of inducing Vpr-mediated cell cycle arrest. These results suggest a model whereby both infectious and noninfectious virions in vivo, such as those surrounding follicular dendritic cells, participate in immune suppression.